Abstract

Objectives: Determine whether a low serum concentration of 25-hydroxyvitamin D, which responsible for bone and calcium metabolism, was associated with type 2 Diabetes.

Study Design: Prospective observational study

Setting: Therapeutic clinic, Azerbaijan Medical University, Baku.

Subjects and intervention: Total 72 patients with type 2 diabetes major more than 45 years of age wereincluded in investigation.

Study period: 7 October 2015 to 22 September 2016

Results: Lower levels of 25(OH)D3 was associated with less good glycemic control in type 2 diabetes mellitus patients. 25(OH)D3 had a negative correlation with HOMA-IR (p<0.001). HOMA-IR and fasting insulin values were lower with higher mean 25(OH)D3 concentrations. Lower serum 25(OH)D3 concentrations also increase serum parathyroid hormone (PTH).At levels <20 ng/ml, 25(OH) D had a negative correlation with PTH (p<0,01). Plasma osteocalcin (OC) concentration, a marker for osteoblastic activity, was markedly lower in diabetic rats than in nondiabetic (8.2±0.7ng/ml vs 29.5±1.4ng/ml; p<0.05).

Conclusion: Vitamin D possibly plays a role in formation glucose homeostasis. There is a negative correlation between serum levels of vitamin D and insulin resistance. In consequence, this findings demonstrated that vitamin D concentration in diabetic patients was obviously lower in comparison to non-diabetic individuals.